ARG44168
anti-MARCHF2 antibody
anti-MARCHF2 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MARCHF2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MARCHF2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human MARCHF2 |
| Conjugation | Un-conjugated |
| Protein Full Name | E3 ubiquitin-protein ligase MARCHF2 |
| Alternate Names | MARCHF2; Membrane Associated Ring-CH-Type Finger 2; MARCH-II; RNF172; HSPC240; MARCH2; Membrane-Associated Ring Finger (C3HC4) 2, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase MARCHF2; Membrane-Associated RING Finger Protein 2; Membrane-Associated RING-CH Protein II; E3 Ubiquitin-Protein Ligase MARCHF2; RING Finger Protein 172; Membrane-Associated Ring Finger (C3HC4) 2; RING-Type E3 Ubiquitin Transferase MARCH2; E3 Ubiquitin-Protein Ligase MARCH2; Membrane Associated Ring Finger 2; EC 2.3.2.27; EC 6.3.2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9P0N8 Human E3 ubiquitin-protein ligase MARCH2 |
|---|---|
| Gene Symbol | MARCHF2 |
| Gene Full Name | Membrane Associated Ring-Ch-Type Finger 2 |
| Background | MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking. |
| Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| Cellular Localization | Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane |
| Calculated MW | 27 kDa |
