ARG43908
anti-MCL1 antibody
anti-MCL1 antibody for ELISA,Flow cytometry,ICC/IF,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MCL1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Predict Reactivity | Ms |
| Tested Application | ELISA, FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MCL1 |
| Antigen Species | Human |
| Immunogen | Human MCL1 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Alternate Names | MCL1; MCL1 Apoptosis Regulator, BCL2 Family Member; BCL2L3; Mcl-1; Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1; Myeloid Cell Leukemia Sequence 1 (BCL2-Related); MCL1, BCL2 Family Apoptosis Regulator; Bcl-2-Related Protein EAT/Mcl1; Myeloid Cell Leukemia 1; Bcl-2-Like Protein 3; Bcl2-L-3; Mcl1/EAT; BCL2 Family Apoptosis Regulator; Myeloid Cell Leukemia ES; MCL1-ES; MCL1L; MCL1S; EAT; TM |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified with Immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q07820 Human Induced myeloid leukemia cell differentiation protein Mcl-1 Swiss-port # Q9Z1P3 Rat Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
|---|---|
| Gene Symbol | MCL1 |
| Gene Full Name | MCL1 Apoptosis Regulator, BCL2 Family Member |
| Background | This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010] |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Cellular Localization | Cytoplasm, Membrane, Mitochondrion, Nucleus |
| Calculated MW | 37 kDa |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation |
Images (4) Click the Picture to Zoom In
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ARG43908 anti-MCL1 antibody ICC/IF image
Immunofluorescence: PC-3 cells stained with ARG43908 anti-MCL1 antibody at 5 μg/ml dilution.
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ARG43908 anti-MCL1 antibody WB
Western blot: Raji, Ramos and MCF-7 stained with ARG43908 anti-MCL1 antibody at 0.5 μg/mL dilution.
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ARG43908 anti-MCL1 antibody FACS image
Flow Cytometry: RT4 cells stained with ARG43908 anti-MCL1 antibody (blue) at 1 μg/1x10^6 cells dilution.
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ARG43908 anti-MCL1 antibody WB
Western blot: Rat stomach and Rat kidney with ARG43908 anti-MCL1 antibody at 0.5 μg/mL dilution.
