ARG44988
anti-MIZ1 antibody
anti-MIZ1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes MIZ1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | MIZ1 |
| Antigen Species | Human |
| Epitope | GSEVSVVTVD DMVTLATEAL AATAVTQLTV VPVGAAVTAD ETEVLKAEIS KAVKQVQEED PNTHILYACD SCGDKFLDAN SLAQHVRIHT AQALVMFQTD |
| Conjugation | Un-conjugated |
| Alternate Names | ZBTB17; Zinc Finger And BTB Domain Containing17; Zinc Finger Protein60; PHZ-67; ZNF151; ZNF60; MIZ1; Zinc Finger And BTB Domain-Containing Protein17; Zinc Finger Protein151 (PHZ-67); Myc-Interacting Zinc Finger Protein1; Myc-Interacting Zn Finger Protein-1; Zinc Finger Protein151; MIZ-1; Miz-1 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | ZBTB17 |
|---|---|
| Gene Full Name | Zinc Finger And BTB Domain Containing17 |
| Background | This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome18. [provided by RefSeq, Jul2008] |
| Function | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform3/ZNF509S1. [Uniprot] |
| Cellular Localization | Nucleus. [Uniprot] |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
