ARG57985

anti-MMP25 antibody

anti-MMP25 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes MMP25
Tested Reactivity Hu
Tested Application IHC-P
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MMP25
Antigen Species Human
Immunogen Synthetic peptide of Human MMP25.
Conjugation Un-conjugated
Alternate Names Membrane-type-6 matrix metalloproteinase; Membrane-type matrix metalloproteinase 6; EC 3.4.24.-; MT-MMP 6; MMP-25; MMPL1; MT6-MMP; MMP20A; MT6MMP; Leukolysin; Matrix metalloproteinase-25; MTMMP6; MT-MMP6; MMP20

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 64386 Human MMP25

Swiss-port # Q9NPA2 Human Matrix metalloproteinase-25

Gene Symbol MMP25
Gene Full Name matrix metallopeptidase 25
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Function May activate progelatinase A. [UniProt]
Cellular Localization Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Secreted, extracellular matrix, extracellular space. [UniProt]
Calculated MW 63 kDa
PTM The precursor is cleaved by a furin endopeptidase. [UniProt]