ARG66424

anti-MMP7 (active) antibody [SQab18126]

anti-MMP7 (active) antibody [SQab18126] for ELISA,Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [SQab18126] recognizes MMP7 (active)
Tested Reactivity Hu
Tested Application ELISA, FACS, ICC/IF, IHC-P, WB
Host Mouse
Clonality Monoclonal
Clone SQab18126
Isotype IgG2a, kappa
Target Name MMP7 (active)
Antigen Species Human
Immunogen Recombinant Human MMP7 protein.
Conjugation Un-conjugated
Alternate Names MMP-7; Uterine metalloproteinase; Matrix metalloproteinase-7; EC 3.4.24.23; Matrilysin; Matrin; Pump-1 protease; PUMP-1; MPSL1

Application Instructions

Application Suggestion
Tested Application Dilution
ELISA1:3000 - 1:10000
FACS1:400 - 1:1000
ICC/IF1:400 - 1:1000
IHC-PAssay-dependent
WB1:2500 - 1:5000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Purification Affinity purification with immunogen.
Buffer PBS (pH 7.4) and 0.01% Thimerosal.
Preservative 0.01% Thimerosal
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 4316 Human MMP7

Swiss-port # P09237 Human Matrilysin

Gene Symbol MMP7
Gene Full Name matrix metallopeptidase 7
Background MMP7 is a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
Function MMP7 degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. [UniProt]
Cellular Localization Secreted, extracellular space, extracellular matrix. [UniProt]
Calculated MW 30 kDa