ARG22192
anti-MMP9 antibody [SB15c] (HRP)
anti-MMP9 antibody [SB15c] (HRP) for ELISA,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Western blot and Human
Brain Injury IHC Study antibody
Overview
| Product Description | HRP-conjugated Mouse Monoclonal antibody [SB15c] recognizes MMP9 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, ICC/IF, IHC-P, WB |
| Specificity | Human/Mouse MMP-9 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | SB15c |
| Isotype | IgG2a, kappa |
| Target Name | MMP9 |
| Antigen Species | Human |
| Immunogen | Recombinant full length Human MMP-9 |
| Conjugation | HRP |
| Alternate Names | Matrix metalloproteinase-9; 92 kDa gelatinase; MMP-9; Gelatinase B; GELB; CLG4B; MANDP2; EC 3.4.24.35; 92 kDa type IV collagenase |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 50% PBS (pH 7.4) and 50% Glycerol |
| Stabilizer | 50% Glycerol |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MMP9 |
| Gene Full Name | matrix metallopeptidase 9 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] |
| Function | May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. [UniProt] |
| Research Area | Brain Injury IHC Study antibody |
| Calculated MW | 78 kDa |
| PTM | Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. N- and O-glycosylated. |
