ARG42605

anti-MOSC1 antibody

anti-MOSC1 antibody for Western blot and Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes MOSC1
Tested Reactivity Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MOSC1
Antigen Species Human
Immunogen Synthetic peptide derived from Human MOSC1.
Conjugation Un-conjugated
Alternate Names Mitochondrial amidoxime-reducing component 1; EC 1.-.-.-; MOSC domain-containing protein 1; MOSC1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1; Moco sulfurase C-terminal domain-containing protein 1; mARC1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control NIH/3T3
Observed Size ~ 37 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.5% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 66112 Mouse MARC1

GeneID: 72925 Mouse MARC1

Swiss-port # Q6NZQ8 Mouse E3 ubiquitin-protein ligase MARCH1

Swiss-port # Q9CW42 Mouse Mitochondrial amidoxime-reducing component 1

Gene Symbol MARC1
Gene Full Name mitochondrial amidoxime reducing component 1
Function Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771). [UniProt]
Cellular Localization Mitochondrion outer membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP. [UniProt]
Calculated MW 37 kDa