ARG66954

anti-MPO / Myeloperoxidase antibody

anti-MPO / Myeloperoxidase antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse

Inflammatory Cell Marker antibody; Neurophil Marker antibody

Overview

Product Description Mouse Polyclonal antibody recognizes MPO / Myeloperoxidase
Tested Reactivity Hu, Ms
Tested Application IHC-P
Host Mouse
Clonality Polyclonal
Isotype IgG
Target Name MPO / Myeloperoxidase
Antigen Species Human
Immunogen Synthetic peptide of Human MPO / Myeloperoxidase.
Conjugation Un-conjugated
Protein Full Name Myeloperoxidase
Alternate Names MPO; Myeloperoxidase; EC 1.11.2.2; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:50 - 1:200
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human Lung

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol and 0.5% BSA
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 17523 Mouse MPO

GeneID: 4353 Human MPO

Swiss-port # P05164 Human Myeloperoxidase

Swiss-port # P11247 Mouse Myeloperoxidase

Gene Symbol MPO
Gene Full Name myeloperoxidase
Background Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Function Myeloperoxidase (MPO): Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. [UniProt]
Cellular Localization Lysosome. [UniProt]
Highlight Related Antibody Duos and Panels:
ARG30325 Inflammatory Cell Antibody Panel
Related products:
MPO antibodies; MPO ELISA Kits; MPO Duos / Panels; Anti-Mouse IgG secondary antibodies;
Related news:
Exploring Antiviral Immune Response
Research Area Inflammatory Cell Marker antibody; Neurophil Marker antibody
Calculated MW 60 kDa, 84 kDa, 89 kDa