ARG64641

anti-MSH5 antibody

anti-MSH5 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human

Gene Regulation antibody

Overview

Product Description Goat Polyclonal antibody recognizes MSH5
Tested Reactivity Hu
Predict Reactivity Ms, Rat
Tested Application IHC-P
Specificity This antibody is expected to recognise three reported isoforms ( NP_079535.3 ; NP_751897.1; NP_002432.1); Reported variants NP_751898.1 and NP_002432.1 represent identical protein.
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name MSH5
Antigen Species Human
Immunogen GDLHCEIRDQET
Conjugation Un-conjugated
Alternate Names G7; NG23; hMSH5; MutS protein homolog 5; MUTSH5

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P2 - 4 µg/ml
Application Note IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 4439 Human MSH5

Swiss-port # O43196 Human MutS protein homolog 5

Background This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Research Area Gene Regulation antibody
Calculated MW 93 kDa