ARG43071

anti-MTA2 antibody

anti-MTA2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Flow cytometry and Human

Overview

Product Description Rabbit Polyclonal antibody recognizes MTA2
Tested Reactivity Hu
Tested Application FACS, ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MTA2
Antigen Species Human
Immunogen Synthetic peptide derived from Human MTA2.
Conjugation Un-conjugated
Alternate Names p53 target protein in deacetylase complex; MTA1L1; PID; Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:100
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HeLa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 9219 Human MTA2

Swiss-port # O94776 Human Metastasis-associated protein MTA2

Gene Symbol MTA2
Gene Full Name metastasis associated 1 family, member 2
Background This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Function May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. [UniProt]
Cellular Localization Nucleus. [UniProt]
Calculated MW 75 kDa