ARG57589

anti-MTNR1A antibody

anti-MTNR1A antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

publication_link Publication1

Overview

Product Description

Rabbit Polyclonal antibody recognizes MTNR1A

Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MTNR1A
Antigen Species Human
Immunogen Recombinant protein of Human MTNR1A.
Conjugation Un-conjugated
Alternate Names MEL-1A-R; Mel-1A-R; MT1; Melatonin receptor type 1A; Mel1a receptor

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:100 - 1:200
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse small intestine
Observed Size 39 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide, 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 17773 Mouse MTNR1A

GeneID: 4543 Human MTNR1A

Swiss-port # P48039 Human Melatonin receptor type 1A

Swiss-port # Q61184 Mouse Melatonin receptor type 1A

Gene Symbol MTNR1A
Gene Full Name melatonin receptor 1A
Background This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]
Function High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. [UniProt]
Calculated MW 39 kDa

Specific References

Sleep deprivation during pregnancy leads to poor fetal outcomes in Sprague-Dawley rats

WB / Rat

Jinzhi Li et al.
J Reprod Immunol.,  (2023)

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