ARG45052
anti-MUC17 antibody [RM517]
anti-MUC17 antibody [RM517] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit monoclonal [RM517] recognizes MUC17. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Specificity | This antibody reacts to human Muc17 (Mucin-17) |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | RM517 |
| Isotype | IgG |
| Target Name | MUC17 |
| Immunogen | A peptide corresponding to residues near the C-terminus of human Muc17. |
| Conjugation | Un-conjugated |
| Alternate Names | MUC17; Mucin 17, Cell Surface Associated; Small Intestinal Mucin-3; Mucin-17; MUC-17; MUC-3; MUC3; Small Intestinal Mucin MUC3; Membrane Mucin MUC17; Secreted Mucin MUC17; EC 6.3.2.8; EC 3.1.3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Stabilizer | 50% Glycerol, 1% BSA and 0.09% |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MUC17 |
| Gene Full Name | Mucin 17, Cell Surface Associated |
| Background | The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015] |
| Function | Probably plays a role in maintaining homeostasis on mucosal surfaces. [Uniprot] |
| Cellular Localization | Cell membrane, Membrane, Secreted. [Uniprot] |
| PTM | Disulfide bond, Glycoprotein. [Uniprot] |
