ARG56062
anti-MUC6 / Gastric Mucin antibody [CLH5]
anti-MUC6 / Gastric Mucin antibody [CLH5] for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [CLH5] recognizes MUC6 / Gastric Mucin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CLH5 |
| Isotype | IgG1, kappa |
| Target Name | MUC6 / Gastric Mucin |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of the gastric Mucin 6 tandem repeat sequence. |
| Conjugation | Un-conjugated |
| Alternate Names | Mucin-6; Gastric mucin-6; MUC-6 |
Application Instructions
| Application Suggestion |
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| Application Note | Antigen retrieval for IHC-P: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 0.1 mg/ml BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MUC6 |
| Gene Full Name | mucin 6, oligomeric mucus/gel-forming |
| Background | The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010] |
| Function | May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. [UniProt] |
| Cellular Localization | Cytoplasmic and secreted |
| Highlight | Related products: Anti-Mouse IgG secondary antibodies; Related news: Wnt / beta-catenin signaling for gastric fundus specification More than a biomarker, CA19-9 is a therapeutic target of pancreatic cancer |
| Calculated MW | 257 kDa |
| PTM | O-glycosylated. |
