ARG40486
anti-MYBPC1 antibody
anti-MYBPC1 antibody for Western blot,ICC/IF and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MYBPC1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | ICC/IF, WB |
| Specificity | At least five isoforms of MYBPC1 are known to exist. This antibody is predicted not to cross-react with other MYBPC family members. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MYBPC1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around 18 aa (N-terminus) of Human MYBPC1. |
| Conjugation | Un-conjugated |
| Alternate Names | LCCS4; MYBPCC; Slow MyBP-C; C-protein, skeletal muscle slow isoform; MYBPCS; Myosin-binding protein C, slow-type |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Rat skeletal muscle |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MYBPC1 |
| Gene Full Name | myosin binding protein C, slow type |
| Background | This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| Function | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. [UniProt] |
| Calculated MW | 128 kDa |
