ARG40456
anti-MYH10 antibody
anti-MYH10 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MYH10 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MYH10 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1908-2007 of Human MYH10 (NP_001242941.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Myosin-10; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHCB; Non-muscle myosin heavy chain B; NMMHC II-b; NMMHC-IIB; Myosin heavy chain, non-muscle IIb; Cellular myosin heavy chain, type B; Myosin heavy chain 10 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HT-29 | ||||
| Observed Size | 250 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MYH10 |
| Gene Full Name | myosin, heavy chain 10, non-muscle |
| Background | This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. [UniProt] |
| Cellular Localization | Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells. [UniProt] |
| Calculated MW | 229 kDa |
| PTM | Phosphorylated by ABL2. [UniProt] |
