ARG52342
anti-Munc18-1 phospho (Ser241) antibody
anti-Munc18-1 phospho (Ser241) antibody for Western blot and Mouse
Cancer antibody; Metabolism antibody; Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Munc18-1 phospho (Ser241) |
|---|---|
| Tested Reactivity | Ms |
| Predict Reactivity | Hu, Rat, Bov, Chk, Dog, NHuPrm, Sheep |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Munc18-1 |
| Antigen Species | Mouse |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | p67; Unc18-1; Protein unc-18 homolog A; MUNC18-1; RBSEC1; NSEC1; Protein unc-18 homolog 1; UNC18; Unc-18A; P67; Syntaxin-binding protein 1; N-Sec1 |
Application Instructions
| Application Suggestion |
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| Application Note | Specific for the ~65k Munc18-1 protein phosphorylated at Ser241. Immunolabeling is blocked by the treatment of the lysate with lambda phosphatase (30 minutes, 800 units / 1 mg protein). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | STXBP1 |
| Gene Full Name | syntaxin binding protein 1 |
| Background | Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation. |
| Research Area | Cancer antibody; Metabolism antibody; Neuroscience antibody |
| Calculated MW | 68 kDa |
