ARG42231

anti-NAT8L antibody

anti-NAT8L antibody for ICC/IF,Flow cytometry and Human,Mouse

Overview

Product Description Goat Polyclonal antibody recognizes NAT8L
Tested Reactivity Hu, Ms
Predict Reactivity Cow, Rat, Dog
Tested Application FACS, ICC/IF
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name NAT8L
Antigen Species Mouse
Immunogen Synthetic peptide around the internal region of Mouse NAT8L. (C-SVDSRFRGKGIAK) (NP_001001985.3)
Conjugation Un-conjugated
Alternate Names NAT8-LIKE; N-acetyltransferase 8-like protein; NACED; Camello-like protein 3; NAA synthetase; EC 2.3.1.17; CML3; N-acetylaspartate synthetase

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µg/ml
ICC/IF10 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Ammonium sulphate precipitation followed by affinity purification with immunogen.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 269642 Mouse NAT8L

GeneID: 339983 Human NAT8L

Swiss-port # Q3UGX3 Mouse N-acetylaspartate synthetase

Swiss-port # Q8N9F0 Human N-acetylaspartate synthetase

Gene Symbol NAT8L
Gene Full Name N-acetyltransferase 8-like (GCN5-related, putative)
Background This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]
Function Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. [UniProt]
Cellular Localization Cytoplasm. Membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. [UniProt]
Calculated MW 33 kDa