ARG65563

anti-NDUFA13 antibody

anti-NDUFA13 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes NDUFA13
Tested Reactivity Hu, Ms
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name NDUFA13
Antigen Species Human
Immunogen Fusion protein of human NDUFA13
Conjugation Un-conjugated
Alternate Names CI-B16.6; NADH-ubiquinone oxidoreductase B16.6 subunit; CGI-39; Gene associated with retinoic and interferon-induced mortality 19 protein; Cell death regulatory protein GRIM-19; Complex I-B16.6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; GRIM19; CDA016; B16.6; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P50-200
WB500-2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse spleen and skeletal muscle tissue, Human hepatocellular carcinoma, Mouse liver and Human placenta tissue, HeLa and 293T cell tissue.

Properties

Form Liquid
Purification Purified by antigen-affinity chromatography.
Buffer 1XPBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol
Preservative 0.05% Sodium azide
Stabilizer 40% Glycerol
Concentration 2 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 51079 Human NDUFA13

GeneID: 67184 Mouse NDUFA13

Swiss-port # Q9ERS2 Mouse NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Swiss-port # Q9P0J0 Human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene Symbol NDUFA13
Gene Full Name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Background This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined.
Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. [UniProt]
Highlight Related products:
Anti-Rabbit IgG secondary antibodies;
Related poster download:
The Structure & Functions of Mitochondria.pdf
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody
Calculated MW 17 kDa