ARG65578

anti-NDUFS8 antibody

anti-NDUFS8 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse

Cancer antibody; Controls and Markers antibody; Metabolism antibody; Signaling Transduction antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes NDUFS8
Tested Reactivity Hu, Ms
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name NDUFS8
Antigen Species Human
Immunogen Fusion protein of human NDUFS8
Conjugation Un-conjugated
Alternate Names EC 1.6.5.3; TYKY; NADH-ubiquinone oxidoreductase 23 kDa subunit; CI-23k; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; CI23KD; Complex I-23kD; EC 1.6.99.3; CI-23kD; TYKY subunit

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P25-100
WB500-2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Jurkat cell, mouse heart and brain tissue

Properties

Form Liquid
Purification Purified by antigen-affinity chromatography.
Buffer 1XPBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol
Preservative 0.05% Sodium azide
Stabilizer 40% Glycerol
Concentration 0.9 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 225887 Mouse NDUFS8

GeneID: 4728 Human NDUFS8

Swiss-port # O00217 Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

Swiss-port # Q8K3J1 Mouse NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

Gene Symbol NDUFS8
Gene Full Name NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
Background This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. [UniProt]
Highlight Related products:
NDUFS8 antibodies; Anti-Rabbit IgG secondary antibodies;
Related poster download:
The Structure & Functions of Mitochondria.pdf
Research Area Cancer antibody; Controls and Markers antibody; Metabolism antibody; Signaling Transduction antibody
Calculated MW 24 kDa