ARG40141

anti-NDUFV1 antibody

anti-NDUFV1 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes NDUFV1
Tested Reactivity Hu, Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name NDUFV1
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide between aa. 194-226 of Human NDUFV1.
Conjugation Un-conjugated
Alternate Names CI51KD; UQOR1; EC 1.6.5.3; NADH-ubiquinone oxidoreductase 51 kDa subunit; Complex I-51kD; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; EC 1.6.99.3; NADH dehydrogenase flavoprotein 1; CI-51K; CI-51kD

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HepG2

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide.
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 17995 Mouse NDUFV1

GeneID: 4723 Human NDUFV1

Swiss-port # P49821 Human NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Swiss-port # Q91YT0 Mouse NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Gene Symbol NDUFV1
Gene Full Name NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
Background The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). [UniProt]
Cellular Localization Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. [UniProt]
Calculated MW 51 kDa