ARG51143
anti-NMDAR2B antibody
anti-NMDAR2B antibody for ICC/IF and Human,Mouse,Rat
Neuroscience antibody; Postsynaptic Receptor antibody
Overview
Product Description | Rabbit Polyclonal antibody recognizes NMDAR2B |
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Tested Reactivity | Hu, Ms, Rat |
Tested Application | ICC/IF |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | NMDAR2B |
Antigen Species | Human |
Immunogen | Peptide sequence around aa.1472~1476 (H-V-Y-E-K) derived from Human NMDAR2B. |
Conjugation | Un-conjugated |
Alternate Names | MRD6; EIEE27; NR2B; hNR3; GluN2B; NR3; N-methyl D-aspartate receptor subtype 2B; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; NMDAR2B |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic peptide. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Buffer | PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | GRIN2B |
Gene Full Name | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
Background | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. |
Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). [UniProt] |
Research Area | Neuroscience antibody; Postsynaptic Receptor antibody |
Calculated MW | 166 kDa |
PTM | Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity. |