ARG66078
anti-NNT1 antibody (Biotin)
anti-NNT1 antibody (Biotin) for ELISA and Human
Overview
| Product Description | Biotin-conjugated Rabbit Polyclonal antibody recognizes NNT1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NNT1 |
| Antigen Species | Human |
| Immunogen | E. coli derived recombinant Human NNT1. (MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF) |
| Conjugation | Biotin |
| Alternate Names | NNT-1; BSF-3; CISS2; Novel neurotrophin-1; NR6; Cardiotrophin-like cytokine factor 1; B-cell-stimulating factor 3; CLC; BSF3; NNT1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by affinity chromatography. |
| Buffer | PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UBD9 Human Cardiotrophin-like cytokine factor 1 |
|---|---|
| Gene Symbol | CLCF1 |
| Gene Full Name | cardiotrophin-like cytokine factor 1 |
| Background | This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009] |
| Function | Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. [UniProt] |
| Calculated MW | 25 kDa |
