ARG55352
anti-NR0B1 / DAX1 antibody
anti-NR0B1 / DAX1 antibody for Western blot and Human
Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NR0B1 / DAX1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NR0B1 / DAX1 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 4-34 (N-terminus) of Human DAX1. |
| Conjugation | Un-conjugated |
| Alternate Names | AHC; GTD; SRXY2; DAX1; AHCH; DSS; NROB1; Nuclear receptor subfamily 0 group B member 1; HHG; Nuclear receptor DAX-1; DAX-1; AHX; DSS-AHC critical region on the X chromosome protein 1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HeLa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P51843 Human Nuclear receptor subfamily 0 group B member 1 |
|---|---|
| Gene Symbol | NR0B1 |
| Gene Full Name | nuclear receptor subfamily 0, group B, member 1 |
| Background | This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008] |
| Function | Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus |
| Research Area | Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody |
| Calculated MW | 52 kDa |
