ARG44126
anti-NRDC antibody
anti-NRDC antibody for Flow cytometry,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal recognizes NRDC |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NRDC |
| Antigen Species | Human |
| Immunogen | Human NRD1/NRDC recombinant protein (Position: K427-R967). |
| Conjugation | Un-conjugated |
| Alternate Names | NRDC; Nardilysin Convertase; HNRD1; HNRD2; NRD1; Nardilysin (N-Arginine Dibasic Convertase); N-Arginine Dibasic Convertase; NRD Convertase; EC 3.4.24.61; Nardilysin; EC 3.4.24; NRD-C |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NRDC |
| Gene Full Name | Nardilysin Convertase |
| Background | This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH). |
| Cellular Localization | Cell projection, Mitochondrion |
| Calculated MW | 132 kDa |
| PTM | Phosphoprotein |
