ARG56717
anti-NRG1 / Heregulin beta 1 antibody
anti-NRG1 / Heregulin beta 1 antibody for ELISA,Western blot,Neutralizing and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NRG1 / Heregulin beta 1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, Neut, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NRG1 / Heregulin beta 1 |
| Antigen Species | Human |
| Immunogen | E.coli derived Recombinant Human Heregulinβ-1. (SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE) |
| Conjugation | Un-conjugated |
| Alternate Names | Sensory and motor neuron-derived factor; Heregulin; GGF2; Glial growth factor; Acetylcholine receptor-inducing activity; SMDF; ARIA; NRG1-IT2; Neu differentiation factor; HRGA; NDF; Breast cancer cell differentiation factor p45; HGL; GGF; MSTP131; Pro-NRG1; HRG; MST131; HRG1; Pro-neuregulin-1, membrane-bound isoform |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q02297 Human Pro-neuregulin-1, membrane-bound isoform |
|---|---|
| Gene Symbol | NRG1 |
| Gene Full Name | neuregulin 1 |
| Background | The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014] |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. [UniProt] |
| Calculated MW | 70 kDa |
| PTM | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity). |
