ARG57936
anti-NRG4 antibody
anti-NRG4 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NRG4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NRG4 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-115 of Human NRG4 (NP_612640.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Pro-neuregulin-4, membrane-bound isoform; NRG-4; Pro-NRG4; HRG4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8WWG1 Human Pro-neuregulin-4, membrane-bound isoform Swiss-port # Q9WTX4 Mouse Pro-neuregulin-4, membrane-bound isoform |
|---|---|
| Gene Symbol | NRG4 |
| Gene Full Name | neuregulin 4 |
| Background | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008] |
| Function | Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). [UniProt] |
| Cellular Localization | Cell membrane, Secreted, Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 13 kDa |
| PTM | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. Extensive glycosylation precedes the proteolytic cleavage. [UniProt] |
