ARG41984
anti-NSD3 antibody
anti-NSD3 antibody for Western blot,Flow cytometry and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NSD3 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NSD3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human NSD3. |
| Conjugation | Un-conjugated |
| Alternate Names | Wolf-Hirschhorn syndrome candidate 1-like protein 1; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; EC 2.1.1.43; WHSC1-like protein 1; Histone-lysine N-methyltransferase NSD3; NSD3; Protein whistle; Nuclear SET domain-containing protein 3; pp14328 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | MCF7 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6P2L6 Mouse Histone-lysine N-methyltransferase NSD3 Swiss-port # Q9BZ95 Human Histone-lysine N-methyltransferase NSD3 |
|---|---|
| Gene Symbol | WHSC1L1 |
| Gene Full Name | Wolf-Hirschhorn syndrome candidate 1-like 1 |
| Background | This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015] |
| Function | Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. [UniProt] |
| Cellular Localization | Nucleus. Chromosome. [UniProt] |
| Calculated MW | 162 kDa |
