ARG44289
anti-NSMase2 antibody
anti-NSMase2 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NSMase2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NSMASE2 |
| Antigen Species | Human |
| Immunogen | NSMase2 synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | SMPD3; Sphingomyelin Phosphodiesterase 3; Neutral Sphingomyelinase II; NSMASE2; Neutral Sphingomyelinase 2; NSMase-2; Sphingomyelin Phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II); EC 3.1.4.12; NSMase2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 1 mg/ml BSA, 0.05% Sodium azide and 50% glycerol |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 1 mg/ml BSA and 50% glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SMPD3 |
| Gene Full Name | Sphingomyelin Phosphodiesterase 3 |
| Background | Predicted to enable phosphatidic acid binding activity; phosphatidylserine binding activity; and sphingomyelin phosphodiesterase activity. Predicted to be involved in positive regulation of exosomal secretion and sphingomyelin metabolic process. Predicted to act upstream of or within several processes, including animal organ development; enzyme linked receptor protein signaling pathway; and sphingolipid metabolic process. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytoplasm. Biomarker of pulmonary emphysema. |
| Function | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. |
| Cellular Localization | Cell membrane, Golgi apparatus, Membrane |
| Calculated MW | 71 kDa |
| PTM | Lipoprotein, Palmitate, Phosphoprotein |
