ARG44377
anti-NUDT15 antibody
anti-NUDT15 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes NUDT15 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | NUDT15 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 |
| Conjugation | Un-conjugated |
| Alternate Names | NUDT15; Nudix Hydrolase 15 ; MTH2; Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15; Nucleotide Triphosphate Diphosphatase NUDT15; MutT Homolog 2; FLJ10956; Probable 7,8-Dihydro-8-Oxoguanine Triphosphatase NUDT15; Nucleoside Diphosphate-Linked Moiety X Motif 15; Probable 8-Oxo-DGTP Diphosphatase NUDT15; 8-Oxo-DGTPase NUDT15; Nudix Motif 15 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% sodium azide and 50% Glycerol. |
| Preservative | 0.02% sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8BG93 Mouse Probable 8-oxo-dGTP diphosphatase NUDT15 Swiss-port # Q9NV35 Human Probable 8-oxo-dGTP diphosphatase NUDT15 |
|---|---|
| Gene Symbol | NUDT15 |
| Gene Full Name | Nudix Hydrolase 15 |
| Background | This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. |
| Function | May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. |
| Calculated MW | 19 kDa |
