ARG56140
anti-Nav1.7 Na+ Channel antibody [S68-6]
anti-Nav1.7 Na+ Channel antibody [S68-6] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Hamster
Overview
| Product Description | Mouse Monoclonal antibody [S68-6] recognizes Nav1.7 Na+ Channel |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Hm |
| Tested Application | IHC-P, WB |
| Specificity | This antibody recognizes Human, Mouse, and Rat Nav1.7. It does not cross-react with other Nav channels. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S68-6 |
| Isotype | IgG1 |
| Target Name | Nav1.7 Na+ Channel |
| Antigen Species | Human |
| Immunogen | Fusion protein around aa. 1751-1946 (cytoplasmic C-terminus) of Human Nav1.7 |
| Conjugation | Un-conjugated |
| Alternate Names | Sodium channel protein type 9 subunit alpha; Nav1.7; PN1; Voltage-gated sodium channel subunit alpha Nav1.7; HSAN2D; NENA; SFNP; NE-NA; hNE-Na; ETHA; Neuroendocrine sodium channel; GEFSP7; Peripheral sodium channel 1; Sodium channel protein type IX subunit alpha; FEB3B |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol. |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SCN9A |
| Gene Full Name | sodium channel, voltage gated, type IX alpha subunit |
| Background | This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009] |
| Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity). [UniProt] |
| Calculated MW | 226 kDa |
| PTM | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. |
