ARG45117
anti-Nkx 3.1 antibody
anti-Nkx 3.1 antibody for Western blot,ICC/IF and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Nkx 3.1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Nkx 3.1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing a sequence within amino acids 1-80 of Human Nkx 3.1 |
| Conjugation | Un-conjugated |
| Alternate Names | NKX3-1; NK3 Homeobox 1; NKX3.1; BAPX2; NKX3A; Homeobox Protein NK-3 Homolog A; Homeobox Protein Nkx-3.1; NK3 Transcription Factor Related, Locus 1 (Drosophila); NK3 Transcription Factor Related, Locus 1; NK Homeobox (Drosophila), Family 3, A; NK3 Transcription Factor Homolog A; NK Homeobox, Family 3, A; NKX3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.05% Proclin300 and 50% Glycerol. |
| Preservative | 0.05% Proclin300 |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NKX3-1 |
| Gene Full Name | NK3 Homeobox 1 |
| Background | This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012] |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. [Unuprot] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 26 kDa |
| PTM | Ubl conjugation. [UniProt] |
