ARG23976
anti-NrCAM antibody [S364-51]
anti-NrCAM antibody [S364-51] for Western blot and Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S364-51] recognizes NrCAM |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S364-51 |
| Isotype | IgG2a |
| Target Name | NrCAM |
| Antigen Species | Mouse |
| Immunogen | Fusion protein corresponding to aa. 30-845 (extracellular domain) of Mouse NrCAM. |
| Conjugation | Un-conjugated |
| Alternate Names | Nr-CAM; Ng-CAM-related; hBravo; Neuronal surface protein Bravo; Neuronal cell adhesion molecule; NgCAM-related cell adhesion molecule |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | ~ 145 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.1% Sodium azide and 50% Glycerol. |
| Preservative | 0.1% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NRCAM |
| Gene Full Name | neuronal cell adhesion molecule |
| Background | Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Function | Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity). [UniProt] |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted. Note=Detected at nodes of Ranvier. [UniProt] |
| Calculated MW | 144 kDa |
