ARG52375

anti-Nuclear pore Complex antibody [39C7]

anti-Nuclear pore Complex antibody [39C7] for ICC/IF,Western blot and Human,Mouse

Controls and Markers antibody; Gene Regulation antibody

Overview

Product Description

Mouse Monoclonal antibody [39C7] recognizes Nuclear pore Complex

Tested Reactivity Hu, Ms
Tested Application ICC/IF, WB
Host Mouse
Clonality Monoclonal
Clone 39C7
Isotype IgG1
Target Name Nuclear pore Complex
Immunogen Yeast nuclear preparations.
Conjugation Un-conjugated

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:100 - 1:500 (yeast cells); 1:50 - 1:100 (mammalian cells)
WB1:100
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Unpurified
Buffer Tissue culture supernatant.
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol Nuclear stain of multiple gene products including Nup62, Nup133
Background The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).
Research Area Controls and Markers antibody; Gene Regulation antibody

Clone References

Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.

Ljubojevic S et al.
Circulation.,  (2014)

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