ARG11088
anti-Nurr1 antibody
anti-Nurr1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Nurr1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Nurr1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 566-591 of Human Nurr1. (CTQGL QRIFY LKLED LVPPP AIIDK L) |
| Conjugation | Un-conjugated |
| Alternate Names | TINUR; Orphan nuclear receptor NURR1; NURR1; Immediate-early response protein NOT; HZF-3; Transcriptionally-inducible nuclear receptor; NOT; Nuclear receptor subfamily 4 group A member 2; RNR1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 65 - 75 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris, HCl/Glycine buffer (pH 7.4-7.8), cryo-protective agents, Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.61 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P43354 Human Nuclear receptor subfamily 4 group A member 2 Swiss-port # Q06219 Mouse Nuclear receptor subfamily 4 group A member 2 |
|---|---|
| Gene Symbol | NR4A2 |
| Gene Full Name | nuclear receptor subfamily 4, group A, member 2 |
| Background | This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. [UniProt] |
| Calculated MW | 67 kDa |
