ARG54924
anti-OASL antibody
anti-OASL antibody for ELISA,ICC/IF,Western blot and Human,Mouse,Rat
Cell Biology and Cellular Response antibody; Immune System antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes OASL |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, ICC/IF, WB |
| Specificity | OASL antibody is human, mouse and rat reactive. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | OASL |
| Antigen Species | Human |
| Immunogen | Synthetic peptide (17 aa) within the first 50 aa of Human OASL. |
| Conjugation | Un-conjugated |
| Alternate Names | Thyroid receptor-interacting protein 14; p59OASL; TR-interacting protein 14; 2'-5'-OAS-RP; p59 OASL; 2'-5'-oligoadenylate synthase-like protein; p59-OASL; 2'-5'-OAS-related protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; OASLd; TRIP14; TRIP-14 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Mouse Bladder Tissue Lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # G3V645 Rat 2'-5'-oligoadenylate synthase-like protein 1 Swiss-port # Q15646 Human 2'-5'-oligoadenylate synthase-like protein |
|---|---|
| Gene Symbol | OASL |
| Gene Full Name | 2'-5'-oligoadenylate synthetase-like |
| Background | OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains. It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis. Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor. |
| Function | Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody; Immune System antibody |
| Calculated MW | 59 kDa |
