ARG55674

anti-PAH antibody

anti-PAH antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

Overview

Product Description Mouse Monoclonal antibody recognizes PAH
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Mouse
Clonality Monoclonal
Clone 717CT21.1.1
Isotype IgG1, kappa
Target Name PAH
Antigen Species Human
Immunogen KLH-conjugated Synthetic peptide corresponding to aa. 127-161 (Center) of Human PAH.
Conjugation Un-conjugated
Alternate Names PKU; Phe-4-monooxygenase; PAH; PKU1; PH; Phenylalanine-4-hydroxylase; EC 1.14.16.1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:25
WB1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control HepG2

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS and 0.09% (W/V) Sodium azide.
Preservative 0.09% (W/V) Sodium azide.
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 18478 Mouse PAH

GeneID: 5053 Human PAH

Swiss-port # P00439 Human Phenylalanine-4-hydroxylase

Swiss-port # P16331 Mouse Phenylalanine-4-hydroxylase

Gene Symbol PAH
Gene Full Name phenylalanine hydroxylase
Background PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. [provided by RefSeq, Jul 2008]
Calculated MW 52 kDa
PTM Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine.