ARG57008
anti-PAIP2 antibody [1C12]
anti-PAIP2 antibody [1C12] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [1C12] recognizes PAIP2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1C12 |
| Isotype | IgG2b |
| Target Name | PAIP2 |
| Antigen Species | Human |
| Immunogen | Recombinant fragment around aa. 1-127 of Human PAIP2. |
| Conjugation | Un-conjugated |
| Alternate Names | A; PABP-interacting protein 2; Poly; PAIP-2; Polyadenylate-binding protein-interacting protein 2; PAIP2A |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9BPZ3 Human Polyadenylate-binding protein-interacting protein 2 |
|---|---|
| Gene Symbol | PAIP2 |
| Gene Full Name | poly(A) binding protein interacting protein 2 |
| Function | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. [UniProt] |
| Calculated MW | 15 kDa |
| PTM | Ubiquitinated, leading to its degradation by the proteasome. |
