ARG10431
anti-PAPP A antibody [5H9]
anti-PAPP A antibody [5H9] for ELISA,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [5H9] recognizes PAPP A |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, WB |
| Specificity | This antibody is specific to proMBP subunit. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5H9 |
| Isotype | IgG2b |
| Target Name | PAPP A |
| Antigen Species | Human |
| Immunogen | Human PAPP A antigen purified from placental blood (heterotetrameric complex, consisting of PAPP A subunits and proMBP subunits). |
| Conjugation | Un-conjugated |
| Alternate Names | DIPLA1; Pappalysin-1; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPPA1; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPA; IGF-dependent IGFBP-4 protease; EC 3.4.24.79; PAPP-A; ASBABP2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS (pH 7.4) and 0.1% Sodium azide |
| Preservative | 0.1% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PAPPA |
| Gene Full Name | pregnancy-associated plasma protein A, pappalysin 1 |
| Background | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008] |
| Function | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. [UniProt] |
| Calculated MW | 181 kDa |
| PTM | There appear to be no free sulfhydryl groups. |
