ARG44067
anti-PAPSS2 antibody
anti-PAPSS2 antibody for Flow cytometry,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal recognizes PAPSS2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PAPSS2 |
| Antigen Species | Human |
| Immunogen | Human PAPSS2 recombinant protein (Position: E212-H320). |
| Conjugation | Un-conjugated |
| Alternate Names | PAPSS2; 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2; ATPSK2; Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2; PAPS Synthase 2; Adenosine 5'-Phosphosulfate Kinase; SK 2; SK2; Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthethase 2; 3-Prime-Phosphoadenosine 5-Prime-Phosphosulfate Synthase 2; ATP Sulfurylase/Adenosine 5'-Phosphosulfate Kinase; Epididymis Secretory Sperm Binding Protein; ATP Sulfurylase/APS Kinase 2; Sulfate Adenylyltransferase; Adenylyl-Sulfate Kinase; Sulfurylase Kinase 2; PAPS Synthetase 2; EC 2.7.1.25; PAPSS 2; BCYM4 |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O88428 Mouse Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Swiss-port # O95340 Human Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
|---|---|
| Gene Symbol | PAPSS2 |
| Gene Full Name | 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 |
| Background | Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. |
| Function | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. |
| Cellular Localization | Cytosol |
| Calculated MW | 70 kDa |
