ARG10806
anti-PDE6A antibody
anti-PDE6A antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PDE6A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | Confocal, Dot, ELISA, ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PDE6A |
| Antigen Species | Human |
| Immunogen | Synthetic cyclic peptide common to all PDE6 alpha variants. |
| Conjugation | Un-conjugated |
| Alternate Names | RP43; CGPR-A; PDEA; GMP-PDE alpha; PDE V-B1; EC 3.1.4.35; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P16499 Human Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
|---|---|
| Gene Symbol | PDE6A |
| Gene Full Name | phosphodiesterase 6A, cGMP-specific, rod, alpha |
| Background | This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008] |
| Function | This protein participates in processes of transmission and amplification of the visual signal. [UniProt] |
| Calculated MW | 100 kDa |
