ARG44451
anti-PELI2 / Pellino2 antibody
anti-PELI2 / Pellino2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PELI2 / Pellino2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PELI2 / Pellino2 |
| Antigen Species | Human |
| Immunogen | Human PELI2 / Pellino2 recombinant protein |
| Conjugation | Un-conjugated |
| Alternate Names | PELI2; Pellino E3 Ubiquitin Protein Ligase Family Member 2; RING-Type E3 Ubiquitin Transferase Pellino Homolog 2; E3 Ubiquitin-Protein Ligase Pellino Homolog 2; Pellino-2; Pellino (Drosophila) Homolog 2; Pellino Homolog 2 (Drosophila); Protein Pellino Homolog 2; Pellino Homolog 2 |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified with Immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8BST6 Mouse E3 ubiquitin-protein ligase pellino homolog 2 Swiss-port # Q9HAT8 Human E3 ubiquitin-protein ligase pellino homolog 2 |
|---|---|
| Gene Symbol | PELI2 |
| Gene Full Name | Pellino E3 Ubiquitin Protein Ligase Family Member 2 |
| Background | Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in membrane. |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. |
| Calculated MW | 46 kDa |
| PTM | Phosphoprotein |
