ARG45119
anti-PGAM5 antibody
anti-PGAM5 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PGAM5 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PGAM5 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding Human PGAM5. |
| Conjugation | Un-conjugated |
| Alternate Names | PGAM5; PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase; Phosphoglycerate Mutase Family Member 5; Bcl-XL-Binding Protein V68; BXLBv68; PGAM Family Member 5, Serine/Threonine Protein Phosphatase, Mitochondrial; Serine/Threonine-Protein Phosphatase PGAM5, Mitochondrial; MGC5352; EC 3.1.3.16 |
Application Instructions
| Application Suggestion |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.05% Proclin300 and 50% Glycerol. |
| Preservative | 0.05% Proclin300 |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PGAM5 |
| Gene Full Name | PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase |
| Background | Enables GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024] |
| Function | Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria. [Uniprot] |
| Cellular Localization | Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane. [Uniprot] |
| Calculated MW | 32 kDa |
| PTM | Acetylation, Phosphoprotein. [Uniprot] |
