ARG44464

anti-PGC / Progastricsin antibody

anti-PGC / Progastricsin antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PGC / Progastricsin
Tested Reactivity Hu, Ms, Rat
Tested Application FACS, ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PGC / Progastricsin
Antigen Species Human
Immunogen Human PGC / Progastricsin recombinant protein
Conjugation Un-conjugated
Alternate Names PGC; Progastricsin; Pepsinogen C; EC 3.4.23.3; Gastricsin; Progastricsin (Pepsinogen C); Pepsinogen Group II; Preprogastricsin; EC 3.4.23; Pepsin C; PEPC; PGII

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1-3 µg/1x10^6
ICC/IF5 µg/ml
IHC-P2-5 µg/ml
WB0.25-0.5 µg/ml
Application Note The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified with Immunogen.
Buffer 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose.
Preservative 0.05% Sodium azide
Stabilizer 4% Trehalose
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 109820 Mouse PGC

GeneID: 24864 Rat PGC

GeneID: 5225 Human PGC

Gene Symbol PGC
Gene Full Name Progastricsin
Background This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Function Hydrolyzes a variety of proteins.
Cellular Localization Secreted
Calculated MW 42 kDa
PTM Disulfide bond, Zymogen