ARG56405

anti-PITRM1 antibody

anti-PITRM1 antibody for Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PITRM1
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PITRM1
Antigen Species Human
Immunogen Recombinant protein of Human PITRM1
Conjugation Un-conjugated
Alternate Names Presequence protease, mitochondrial; hPreP; EC 3.4.24.-; Metalloprotease 1; MP1; hMP1; Pitrilysin metalloproteinase 1; PreP

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control U87

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 10531 Human PITRM1

GeneID: 69617 Mouse PITRM1

Swiss-port # Q5JRX3 Human Presequence protease, mitochondrial

Swiss-port # Q8K411 Mouse Presequence protease, mitochondrial

Gene Symbol PITRM1
Gene Full Name pitrilysin metallopeptidase 1
Function ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. [UniProt]
Calculated MW 117 kDa
PTM The disulfide bond may lock the enzyme in a closed conformation under oxidized conditions, suggesting that it may participate in redox regulation of the enzyme.