ARG44892
anti-PJA1 antibody
anti-PJA1 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes PJA1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Target Name | PJA1 |
| Antigen Species | Human |
| Epitope | LEEVREPSLQ EEQASLEEGE IPWLQYHEND SSSEGDNDSG HELMQPGVFM LDGNNNLEDD SSVSEDLEVD WSLFDGFADG LGVAEAISYV DPQFLTYMAL EERLAQAMET ALAHLESLAV DVEVANPPAS KESIDALPEI LVTEDHGAVG QEMCCPICCS EYVKGEVATE LPCHHYFHKP |
| Conjugation | Un-conjugated |
| Alternate Names | PJA1; Praja Ring Finger Ubiquitin Ligase 1; RNF70; PRAJA1; Praja Ring Finger 1, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase Praja-1; E3 Ubiquitin-Protein Ligase Praja-1; RING Finger Protein 70; FLJ11830; Praja 1; Praja Ring Finger 1; EC 2.3.2.27; EC 6.3.2; Praja1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | PJA1 |
|---|---|
| Gene Full Name | Praja Ring Finger Ubiquitin Ligase 1 |
| Background | This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting. [Uniprot] |
| Calculated MW | 71 kDa |
| PTM | Phosphoprotein, Ubl conjugation. [Uniprot] |
