ARG65101

anti-PLA2R1 antibody

anti-PLA2R1 antibody for Flow cytometry and Human

Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody

Overview

Product Description Goat Polyclonal antibody recognizes PLA2R1
Tested Reactivity Hu
Predict Reactivity Dog, Pig
Tested Application FACS
Specificity This antibody is expected to recognize all reported isoforms (NP_031392.3; NP_001007268.1; NP_001182570.1).
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name PLA2R1
Antigen Species Human
Immunogen C-EKKKDTPKQHGT
Conjugation Un-conjugated
Alternate Names M-type receptor; Soluble PLA2-R; 180 kDa secretory phospholipase A2 receptor; Soluble PLA2R; PLA2G1R; CLEC13C; PLA2-R; C-type lectin domain family 13 member C; PLA2R; Secretory phospholipase A2 receptor; PLA2IR

Application Instructions

Application Suggestion
Tested Application Dilution
FACS10 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 22925 Human PLA2R1

Swiss-port # Q13018 Human Secretory phospholipase A2 receptor

Background This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Research Area Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Calculated MW 169 kDa
PTM The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).