ARG42790
anti-PLAA / Phospholipase A-2-activating protein antibody
anti-PLAA / Phospholipase A-2-activating protein antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PLAA / Phospholipase A-2-activating protein |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PLAA / Phospholipase A-2-activating protein |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human PLAA / Phospholipase A-2-activating protein. |
| Conjugation | Un-conjugated |
| Alternate Names | PLA2P; PLAP; DOA1; Phospholipase A-2-activating protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | MCF7 | ||||||||
| Observed Size | ~ 78 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y263 Human Phospholipase A-2-activating protein |
|---|---|
| Gene Symbol | PLAA |
| Gene Full Name | phospholipase A2-activating protein |
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Cell junction, synapse. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. [UniProt] |
| Calculated MW | 87 kDa |
