ARG43842
anti-PLCD3 antibody
anti-PLCD3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Goat Polyclonal antibody recognizes PLCD3 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Cow, Dog, Pig |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PLCD3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the internal region of Human PLCD3. |
| Conjugation | Un-conjugated |
| Protein Full Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 |
| Alternate Names | PLCD3; Phospholipase C Delta 3; 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3; Phosphoinositide Phospholipase C-Delta-3; PLC-Delta-3; EC 3.1.4.11; 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-3; Phospholipase C, Delta 3; Phospholipase C-Delta-3; PLC Delta3; KIAA1964 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8N3E9 Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 |
|---|---|
| Gene Symbol | PLCD3 |
| Gene Full Name | Phospholipase C Delta 3 |
| Background | This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008] |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. |
| Cellular Localization | Cytoplasm, Membrane |
| Calculated MW | 89 kDa |
| PTM | Phosphoprotein |
