ARG42988
anti-PLEKHA1 / TAPP1 antibody
anti-PLEKHA1 / TAPP1 antibody for Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PLEKHA1 / TAPP1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PLEKHA1 / TAPP1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human PLEKHA1 / TAPP1. |
| Conjugation | Un-conjugated |
| Alternate Names | Pleckstrin homology domain-containing family A member 1; TAPP1; Tandem PH domain-containing protein 1; TAPP-1; PH domain-containing family A member 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | K562 | ||||||
| Observed Size | ~ 46 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Concentration | Batch dependent |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8BUL6 Mouse Pleckstrin homology domain-containing family A member 1 Swiss-port # Q9HB21 Human Pleckstrin homology domain-containing family A member 1 |
|---|---|
| Gene Symbol | PLEKHA1 |
| Gene Full Name | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 |
| Background | This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Sep 2010] |
| Function | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. [UniProt] |
| Cellular Localization | Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. [UniProt] |
| Calculated MW | 46 kDa |
