ARG42942
anti-PLSCR3 antibody
anti-PLSCR3 antibody for ICC/IF and Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PLSCR3 |
|---|---|
| Tested Reactivity | Rat |
| Tested Application | ICC/IF |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PLSCR3 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-295 of Human PLSCR3 (NP_065093.2). |
| Conjugation | Un-conjugated |
| Alternate Names | Phospholipid scramblase 3; Ca; PL scramblase 3; 2+ |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PLSCR3 |
| Gene Full Name | phospholipid scramblase 3 |
| Function | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. [UniProt] |
| Cellular Localization | Mitochondrion membrane; Single-pass type II membrane protein. [UniProt] |
| Calculated MW | 32 kDa |
| PTM | Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity. [UniProt] |
