ARG42942

anti-PLSCR3 antibody

anti-PLSCR3 antibody for ICC/IF and Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes PLSCR3
Tested Reactivity Rat
Tested Application ICC/IF
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PLSCR3
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 1-295 of Human PLSCR3 (NP_065093.2).
Conjugation Un-conjugated
Alternate Names Phospholipid scramblase 3; Ca; PL scramblase 3; 2+

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:50 - 1:100
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 360549 Rat PLSCR3

Swiss-port # Q6QBQ4 Rat Phospholipid scramblase 3

Gene Symbol PLSCR3
Gene Full Name phospholipid scramblase 3
Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. [UniProt]
Cellular Localization Mitochondrion membrane; Single-pass type II membrane protein. [UniProt]
Calculated MW 32 kDa
PTM Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances flip-flop activity. [UniProt]